What is the dose of epinephrine (adrenaline) for a patient with hypertension?

From the Research

Epinephrine Dosage for Hypertension

• The provided studies do not directly address the dosage of epinephrine for a patient with hypertension.
• However, some studies discuss the use of epinephrine in various medical conditions, including anaphylaxis 1, hypotension during critical care transport 2, cardiac arrest 3, 4, and hypotension in the prehospital setting 5.
• The dosage of epinephrine varies across these studies, with doses ranging from 10-20 μg 2 to 1 mg every 3-5 minutes 4.
• It is essential to note that epinephrine is typically used to treat hypotension, anaphylaxis, or cardiac arrest, rather than hypertension.
• There is no clear evidence to support the use of epinephrine in patients with hypertension, and its administration in this context may even be contraindicated due to the potential for worsening hypertension 1, 2, 5.

Key Findings

• A study on push dose epinephrine use in critical care transport found that the median increase in mean arterial pressure was 13.0 mmHg, and hypotension was resolved in 58.5% of instances 2.
• Another study on cumulative epinephrine dose during cardiac arrest found that higher doses of epinephrine were associated with unfavorable neurologic outcomes 3.
• A study on the efficacy of bolus-dose epinephrine to manage hypotension in the prehospital setting found a significant increase in systolic blood pressure following epinephrine administration 5.

Dosage Considerations

• The optimal dosage of epinephrine for various medical conditions is still a topic of debate and requires further research 1, 2, 3, 4, 5.
• The dosage of epinephrine should be carefully considered, taking into account the patient's individual needs and medical condition 4.