Can long-term use of Cialis (Tadalafil) cause impaired renal function?

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Last updated: March 6, 2025View editorial policy

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From the Guidelines

Long-term use of Cialis (Tadalafil) is not directly associated with impaired renal function, as there is no scientific evidence suggesting a causal link between the two. The provided evidence does not support a direct relationship between Tadalafil use and kidney damage. The studies cited focus on ACE inhibitors, kidney donation, and dietary supplements, which are unrelated to the question of Tadalafil's impact on renal function.

  • The first study 1 discusses the potential causes of acute renal failure (ARF) in patients taking ACE inhibitors, including hypotension, volume depletion, and pre-existing renal vascular disease.
  • The second study 1 examines the use of dietary supplements in living kidney donors and their potential impact on kidney function, highlighting the importance of monitoring for nephrotoxicity in this population. However, neither study addresses the specific question of Tadalafil's effects on renal function. In the absence of direct evidence, it is essential to prioritize the patient's overall health and monitor their kidney function regularly, regardless of Tadalafil use. If concerns about kidney health arise, it is crucial to evaluate the patient's individual risk factors and underlying conditions, rather than attributing potential issues to Tadalafil use alone 1. Regular medical check-ups and maintaining overall health are vital for kidney health, and patients should not be deterred from discussing their Tadalafil use with their healthcare provider.

From the Research

Long-term Use of Cialis (Tadalafil) and Renal Function

  • There are no research papers provided that directly investigate the long-term use of Cialis (Tadalafil) and its effects on renal function.
  • The available studies focus on creatine supplementation 2, 3, kidney function in older adults 4, diuretics in patients with chronic kidney disease 5, and long-term use of cardiovascular drugs 6.
  • None of these studies mention Cialis (Tadalafil) or its potential impact on renal function, making it impossible to draw conclusions based on the provided evidence.
  • Further research would be necessary to determine the effects of long-term Cialis (Tadalafil) use on renal function, as the current studies do not address this topic.

References

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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