Differential Diagnosis for Peeling Skin

• Single most likely diagnosis:
  • Keratolysis exfoliativa: A common, benign condition characterized by peeling of the skin on the palms and soles, often due to excessive moisture, friction, or genetic predisposition.
• Other Likely diagnoses:
  • Eczema (atopic dermatitis): A chronic skin condition that can cause dryness, itching, and peeling of the skin.
  • Psoriasis: An autoimmune condition that speeds up the life cycle of skin cells, causing cells to build up rapidly on the surface of the skin, leading to scaling and peeling.
  • Seborrheic dermatitis: A skin condition that causes scaly patches, red skin, and stubborn dandruff, often accompanied by peeling skin.
  • Contact dermatitis: A type of inflammation of the skin that occurs when the skin comes into contact with an irritant or allergen, leading to peeling, among other symptoms.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed):
  • Staphylococcal scalded skin syndrome (SSSS): A rare but serious condition caused by staphylococcal toxins that can lead to widespread skin peeling and requires prompt medical attention.
  • Toxic epidermal necrolysis (TEN): A life-threatening skin condition usually triggered by medications, leading to widespread skin peeling and detachment.
  • Pemphigus: A group of rare skin disorders that cause blistering of the skin and mucous membranes, which can lead to peeling.
• Rare diagnoses:
  • Kawasaki disease: A rare condition that mainly affects children, causing fever, rash, and peeling of the skin, among other symptoms.
  • Peeling skin syndrome: A rare genetic disorder characterized by continuous shedding of the outer layer of the skin.
  • Netherton syndrome: A rare genetic disorder that affects the skin, hair, and immune system, often presenting with peeling skin.