Can NLRP3 (Nucleotide-binding domain, leucine-rich repeat-containing family, pyrin domain-containing 3) increase cystatin C levels?

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From the Research

NLRP3 and Cystatin C Levels

  • There is no direct evidence in the provided studies to suggest that NLRP3 can increase cystatin C levels 1, 2, 3, 4, 5.
  • The studies focus on the activation and regulation of the NLRP3 inflammasome, its role in inflammatory diseases, and its mechanisms of activation and inhibition.
  • None of the studies mention cystatin C levels or their relationship with NLRP3.

Related Findings

  • The NLRP3 inflammasome is activated by various stimuli, including pathogens, danger-associated molecular patterns, and calcium mobilization 1, 2, 5.
  • The activation of the NLRP3 inflammasome leads to the production of proinflammatory cytokines, such as IL-1β and IL-18, and pyroptotic cell death 3, 4.
  • The leucine-rich repeat (LRR) domain of NLRP3 is required for NLRP3 inflammasome activation in macrophages 3.

Lack of Direct Evidence

  • There are no research papers among the provided evidence that directly investigate the relationship between NLRP3 and cystatin C levels.
  • Further research would be needed to determine if NLRP3 has any effect on cystatin C levels 1, 2, 3, 4, 5.

References

2
Research

New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2024

4
Research

The NLRP3-Inflammasome in Health and Disease.

International journal of molecular sciences, 2022

5
Research

Critical role for calcium mobilization in activation of the NLRP3 inflammasome.

Proceedings of the National Academy of Sciences of the United States of America, 2012

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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