Differential Diagnosis for Polyploid Lesion on the Outer Wall of the Gallbladder

• Single Most Likely Diagnosis
  • Cholesterol polyp: This is the most common type of polyp found in the gallbladder and is usually benign. It is often seen as a polypoid lesion on the wall of the gallbladder.
• Other Likely Diagnoses
  • Adenomatous polyp: These polyps have the potential to become malignant and are less common than cholesterol polyps. They can appear similar on imaging but may have different clinical implications.
  • Inflammatory polyp: These can occur in response to chronic inflammation of the gallbladder and may appear as polypoid lesions on the gallbladder wall.
• Do Not Miss Diagnoses
  • Gallbladder cancer: Although less common, cancer of the gallbladder can present as a polypoid lesion. Early detection is crucial for treatment, making it a critical diagnosis not to miss.
  • Metastasis to the gallbladder: Rarely, metastatic disease from other primary sites can involve the gallbladder, presenting as polypoid lesions.
• Rare Diagnoses
  • Leiomyoma: A rare, benign tumor of smooth muscle origin that can occur in the gallbladder, presenting as a polypoid lesion.
  • Granular cell tumor: A rare tumor that can occur in the gallbladder, usually benign, but can mimic other polypoid lesions in appearance.
  • Hemangioma: A benign vascular tumor that can very rarely occur in the gallbladder, presenting as a polypoid lesion.