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Last updated: August 8, 2025View editorial policy

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Differential Diagnosis for Poor Appetite

  • Single Most Likely Diagnosis
    • Depression: Poor appetite is a common symptom of depression, and it's essential to consider this diagnosis, especially if the patient has a history of mental health issues or is exhibiting other depressive symptoms.
  • Other Likely Diagnoses
    • Gastroesophageal Reflux Disease (GERD): GERD can cause discomfort while eating, leading to a decrease in appetite.
    • Peptic Ulcer Disease: Similar to GERD, peptic ulcers can cause pain and discomfort during meals, resulting in poor appetite.
    • Chronic Kidney Disease: Decreased appetite is a common symptom of chronic kidney disease, particularly in advanced stages.
    • Chronic Liver Disease: Liver disease can lead to a decrease in appetite due to the buildup of toxins and the body's inability to process nutrients.
  • Do Not Miss Diagnoses
    • Cancer: Various types of cancer, such as pancreatic, stomach, or lung cancer, can cause a decrease in appetite. It's crucial to investigate further if other symptoms like weight loss, fatigue, or abdominal pain are present.
    • Infections (e.g., Tuberculosis, HIV): Certain infections can lead to a decrease in appetite, and it's essential to consider these diagnoses, especially if the patient has a compromised immune system or is exhibiting other symptoms like fever or night sweats.
    • Addison's Disease: This rare endocrine disorder can cause a decrease in appetite, among other symptoms like fatigue, weight loss, and low blood pressure.
  • Rare Diagnoses
    • Amyotrophic Lateral Sclerosis (ALS): ALS can cause difficulty swallowing and eating, leading to a decrease in appetite.
    • Creutzfeldt-Jakob Disease: This rare neurodegenerative disorder can cause a range of symptoms, including a decrease in appetite.
    • Whipple's Disease: A rare bacterial infection that can cause malabsorption and a decrease in appetite.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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