From the Research
Moles typically begin developing in early childhood and continue to appear throughout life, with the average age of mole development occurring between childhood and young adulthood (ages 5-35). Most people acquire the majority of their moles during the first two decades of life, with peak development during puberty when hormonal changes stimulate melanocyte activity 1. By adulthood (around age 35), most individuals have between 10-40 moles on their body, though this number varies widely based on genetic factors and sun exposure. After middle age, new mole formation typically decreases, and existing moles may fade or disappear with advancing age. Sun exposure significantly influences mole development, with individuals who experience more sun exposure, particularly during childhood, typically developing more moles. This pattern of development reflects the complex interaction between genetic predisposition and environmental factors, particularly ultraviolet radiation, which stimulates melanocytes (the pigment-producing cells) to form moles. Some key factors associated with a mole-prone phenotype include baseline total nevus count and increased variability of nevus dermoscopic pattern 1. Regular skin checks are recommended throughout life to monitor changes in existing moles and the appearance of new ones, as significant changes could indicate potential skin cancer. The clinical, dermoscopic, and histopathological features of common acquired melanocytic nevi have been examined in recent studies, providing valuable insights into the diagnosis and management of these lesions 2. However, the average age of mole development remains a crucial aspect of understanding the natural history of these lesions and their potential relationship to skin cancer. It is essential to note that some studies may not be directly relevant to the question of average age of mole development, and their findings should be considered in the context of the specific research question being addressed 3, 4, 5.