Differential Diagnosis for Numbness between the Large and Middle Toe
- Single most likely diagnosis
- Morton's neuroma: This condition is characterized by the thickening of tissue around a nerve in the foot, often between the third and fourth toes, but can also occur between the first and second toes. It leads to numbness, pain, and discomfort in the affected area, making it a likely cause for the described symptoms.
- Other Likely diagnoses
- Intermetatarsal bursitis: Inflammation of the bursae between the metatarsal bones can cause pain and numbness in the surrounding areas, including between the toes.
- Metatarsalgia: This condition involves pain and inflammation in the ball of the foot, which can radiate to the toes and cause numbness.
- Toe or foot trauma: Direct injury to the toes or foot can cause nerve damage leading to numbness.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Peripheral artery disease (PAD): Although less common, PAD can cause numbness in the feet due to reduced blood flow. Missing this diagnosis could lead to severe complications, including gangrene and amputation.
- Diabetic neuropathy: Individuals with diabetes are at risk for nerve damage, which can cause numbness in the feet. Early detection is crucial to prevent further complications.
- Deep vein thrombosis (DVT): A blood clot in the deep veins of the leg can cause numbness, pain, and swelling. DVT is a medical emergency due to the risk of pulmonary embolism.
- Rare diagnoses
- Tarsal tunnel syndrome: Similar to carpal tunnel syndrome, this condition involves compression of the posterior tibial nerve as it travels through the tarsal tunnel, leading to numbness and pain in the foot and toes.
- Neuroma of the foot (other than Morton's): Although less common, other types of neuromas can occur in the foot, causing numbness and pain.
- Nerve entrapment syndromes: Various nerves in the foot can become entrapped, leading to numbness and pain. These are less common but should be considered in the differential diagnosis.