Is there a difference between Aquaphor (petrolatum) and Vaseline (petrolatum)?

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Last updated: February 9, 2025View editorial policy

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From the Research

Difference between Aquaphor and Vaseline

  • Both Aquaphor and Vaseline are petrolatum-based products, but there is limited research directly comparing the two.
  • A study on Vaseline Petroleum Jelly (VPJ) found that it accelerated barrier recovery and permeated throughout the stratum corneum interstices, allowing normal barrier recovery despite its occlusive properties 1.
  • Another study compared a newly developed petrolatum-based ointment (NOV® II Moisture Balm) with white petrolatum and found that both were effective in moisturizing and improving skin conditions, but the new ointment had superior usability 2.
  • There is no direct comparison between Aquaphor and Vaseline in the provided studies, but both are petrolatum-based and likely have similar moisturizing properties.
  • Petrolatum has been shown to have an immediate barrier-repairing effect in delipidized stratum corneum and can modulate antimicrobials and epidermal differentiation barrier measures 3, 4.

Petrolatum Properties

  • Petrolatum is often used to suppress water evaporation from the skin surface and has been shown to accelerate barrier recovery 1.
  • It can permeate throughout the stratum corneum interstices, allowing normal barrier recovery despite its occlusive properties 1.
  • Petrolatum has been found to have an immediate barrier-repairing effect in delipidized stratum corneum and can improve skin conditions such as atopic dermatitis and dry skin 3, 4.

Usability and Effectiveness

  • A study found that a newly developed petrolatum-based ointment had superior usability compared to white petrolatum, with subjects feeling it spread better and was less sticky and shiny 2.
  • Petrolatum has been shown to be effective in treating pressure ulcers and can reduce transepidermal water loss (TEWL) in atopic and ichthyotic patients 5, 3.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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