Can a celiac plexus block be used for pain management in Nissen fundoplication?

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Last updated: August 11, 2025View editorial policy

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Celiac Plexus Block for Nissen Fundoplication Pain Management

Celiac plexus block is not recommended for pain management following Nissen fundoplication surgery as there is no evidence supporting its use for this indication, and it should be reserved primarily for cancer pain, particularly pancreatic cancer.

Indications for Celiac Plexus Block

Celiac plexus block (CPB) has specific, evidence-based indications that do not include post-Nissen fundoplication pain:

  • Primary indication: Pain from pancreatic cancer (72-80% efficacy) 1
  • Limited efficacy in chronic pancreatitis (51-59% efficacy) 1
  • Specifically recommended against routine use in chronic pancreatitis 1
  • No evidence supporting use for post-surgical pain following Nissen fundoplication 2

Anatomical Considerations

The celiac plexus innervates specific abdominal organs:

  • Liver, pancreas, spleen, omentum
  • Alimentary tract to mid-transverse colon
  • Adrenal glands and kidneys 3, 4

Nissen fundoplication involves the gastroesophageal junction and proximal stomach, which are primarily innervated by the vagus nerve rather than the celiac plexus. This anatomical mismatch makes celiac plexus block inappropriate for targeting post-fundoplication pain.

Appropriate Pain Management for Nissen Fundoplication

Instead of celiac plexus block, post-Nissen fundoplication pain should be managed with:

  1. Standard multimodal analgesia:

    • NSAIDs
    • Acetaminophen
    • Short-term opioids as needed
  2. For refractory cases:

    • Intercostal nerve blocks
    • Thoracic epidural analgesia
    • Thoracic paravertebral blocks

Risks and Complications of Celiac Plexus Block

Using celiac plexus block for an unproven indication exposes patients to unnecessary risks:

  • Hypotension
  • Diarrhea
  • Retroperitoneal hematoma
  • Peripancreatic abscess formation 1
  • Neurologic complications 5

Conclusion

Celiac plexus block should be reserved for its evidence-based indications, primarily pancreatic cancer pain. For Nissen fundoplication, standard post-surgical pain management approaches are more appropriate and supported by evidence. The American Gastroenterological Association and other guidelines do not support using celiac plexus block for post-surgical pain management in this context 1, 2.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Celiac Plexus Block for Endometriosis-Related Pain

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Celiac plexus block in the management of chronic abdominal pain.

Current pain and headache reports, 2014

Research

Celiac plexus block: efficacy and safety of the anterior approach.

AJR. American journal of roentgenology, 1993

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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