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Last updated: August 11, 2025View editorial policy

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Differential Diagnosis for a Patient with a Fib

  • Single most likely diagnosis:
    • Atrial Fibrillation (AFib): This is the most likely diagnosis given the mention of "a fib," which is a common abbreviation for atrial fibrillation. AFib is a type of irregular, rapid heart rhythm that can lead to symptoms such as palpitations, shortness of breath, and fatigue.
  • Other Likely diagnoses:
    • Other cardiac conditions: Given the context of a fib, other cardiac conditions such as coronary artery disease, heart failure, or valvular heart disease could be considered, as they may coexist with or contribute to the development of AFib.
    • Hyperthyroidism: This condition can cause AFib and should be considered, especially if the patient has symptoms such as weight loss, exophthalmos, or heat intolerance.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.):
    • Pulmonary Embolism (PE): Although less likely, PE is a life-threatening condition that can cause sudden onset of shortness of breath and palpitations, similar to AFib. It is crucial to rule out PE, especially if the patient has risk factors such as recent travel, surgery, or cancer.
    • Cardiac Tamponade: This is a life-threatening condition where fluid accumulates in the pericardial sac, compressing the heart. It can cause symptoms similar to heart failure or AFib and requires immediate attention.
  • Rare diagnoses:
    • Wolff-Parkinson-White (WPW) Syndrome: A rare condition characterized by an accessory electrical pathway in the heart, which can cause AFib or other arrhythmias.
    • Cardiac Sarcoidosis: A rare condition where granulomas form in the heart, potentially leading to arrhythmias, including AFib.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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