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Last updated: August 11, 2025View editorial policy

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Differential Diagnosis for Dry, Flaky, Sometimes Painful Red Scalp

  • Single Most Likely Diagnosis
    • Seborrheic dermatitis: This condition is characterized by a red, itchy, and flaky scalp, often accompanied by inflammation. It's a common condition that matches the symptoms described.
  • Other Likely Diagnoses
    • Psoriasis: This autoimmune condition can cause red, scaly patches on the scalp, which may be painful and itchy. The symptoms can vary in severity.
    • Dandruff: A mild form of seborrheic dermatitis, dandruff causes flakes of skin to appear on the scalp, often with itchiness but less commonly with pain.
    • Eczema (atopic dermatitis): This condition can affect the scalp, leading to dryness, flakiness, and redness, often with itchiness and sometimes pain.
  • Do Not Miss Diagnoses
    • Lupus: Systemic lupus erythematosus can cause scalp lesions that are painful and lead to scarring. Although less common, missing this diagnosis could have significant consequences.
    • Sarcoidosis: This condition can cause skin lesions and rashes, including on the scalp, which might be painful and could lead to more serious health issues if not addressed.
    • Infections (bacterial, fungal, or viral): Certain infections can cause painful, red, and flaky scalp conditions. Identifying and treating the underlying infection is crucial.
  • Rare Diagnoses
    • Pityriasis amiantacea: A rare condition characterized by thick, yellow scales on the scalp, which can be associated with psoriasis or seborrheic dermatitis.
    • Lichen planus: An inflammatory condition that can affect the skin and mucous membranes, sometimes causing lesions on the scalp that are painful and itchy.
    • Discoid lupus erythematosus: A chronic skin condition of sores with inflammation and scarring favoring the face, ears, and scalp but can be limited to the scalp, leading to hair loss.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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