From the Research
Urolithin A may interact with several medications, particularly those metabolized by cytochrome P450 enzymes and drugs transported by P-glycoprotein, and individuals taking prescription medications should consult their healthcare provider before considering urolithin A supplements. The potential interactions between urolithin A and medications are not fully characterized, but research suggests that urolithin A can influence drug-metabolizing enzymes and transporters in the body, potentially altering the effectiveness or side effect profile of medications 1. Some medications that could potentially interact with urolithin A include:
- Certain statins (like atorvastatin and simvastatin)
- Blood thinners (such as warfarin)
- Some antibiotics (erythromycin, clarithromycin)
- Antifungals (ketoconazole, itraconazole)
- Immunossuppressants (cyclosporine, tacrolimus) Urolithin A might also interact with medications that affect gut microbiota, like antibiotics, as it is produced by gut bacteria from ellagitannins found in foods like pomegranates and berries 2, 3. It is essential to note that the exact nature and clinical significance of these interactions are not fully understood, and more research is needed to confirm and assess the potential interactions between urolithin A and medications 4, 5. Therefore, it is crucial for individuals taking prescription medications to consult with their healthcare provider before considering urolithin A supplements to ensure safe and effective use.