What food to avoid in hyperbilirubinemia (elevated bilirubin levels) in adults?

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Last updated: March 7, 2025View editorial policy

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From the Guidelines

In adults with hyperbilirubinemia, it is crucial to avoid ultra-processed foods rich in sugars and saturated fat, as well as sugar-sweetened beverages, to improve liver function and reduce bilirubin levels. This recommendation is based on the most recent and highest quality study available, which suggests that improving diet quality, similar to the Mediterranean dietary pattern, can improve histologically or non-invasively assessed liver injury 1.

Some key foods to avoid include:

  • Ultra-processed foods containing high amounts of sugar and saturated fat
  • Sugar-sweetened beverages
  • Foods high in fructose, such as high-fructose corn syrup, agave nectar, and certain fruits like apples, pears, and watermelon
  • Processed meats and foods containing artificial additives, preservatives, and trans fats

Instead, focus on a diet rich in:

  • Fiber (vegetables, whole grains)
  • Lean proteins
  • Foods with antioxidant properties like berries, nuts, and green tea
  • Staying well-hydrated with water to support liver function and bilirubin excretion.

Additionally, limiting alcohol consumption is essential as it directly stresses the liver and impairs its ability to process bilirubin 1. By avoiding these harmful foods and adopting a healthier diet, individuals with hyperbilirubinemia can reduce their liver burden, support detoxification processes, and potentially lower their elevated bilirubin levels while the underlying cause is being treated.

From the Research

Foods to Avoid in Hyperbilirubinemia

There is no direct evidence from the provided studies that specifies particular foods to avoid in hyperbilirubinemia in adults.

General Guidance on Hyperbilirubinemia

  • Hyperbilirubinemia can be caused by various factors, including increased bilirubin production, impaired bilirubin conjugation, hepatocellular damage, and cholestatic disorders 2, 3, 4, 5.
  • Evaluation of hyperbilirubinemia involves a comprehensive medical history, physical examination, laboratory tests, and imaging studies to determine the underlying cause 2, 4, 5.
  • The management of hyperbilirubinemia depends on the underlying cause and may involve treatment of the underlying disease, as well as measures to reduce bilirubin levels 3, 4.

Dietary Considerations

While there is no specific evidence on foods to avoid in hyperbilirubinemia, it is generally recommended to maintain a healthy diet and lifestyle to support liver health 6.

  • A healthy diet may help alleviate symptoms and support the management of underlying conditions that contribute to hyperbilirubinemia.
  • However, without specific evidence, it is not possible to provide a list of foods to avoid in hyperbilirubinemia.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Evaluation of Jaundice in Adults.

American family physician, 2017

Research

The patient presenting with isolated hyperbilirubinemia.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2009

Research

Diagnosis and evaluation of hyperbilirubinemia.

Current opinion in gastroenterology, 2017

Research

Evaluation of Jaundice in Adults.

American family physician, 2025

Research

Bilirubin in clinical practice: a review.

Liver international : official journal of the International Association for the Study of the Liver, 2008

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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