What is the management of a hypoglycemic (low blood sugar) emergency?

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Last updated: August 13, 2025View editorial policy

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Management of Hypoglycemic Emergencies

For hypoglycemic emergencies, immediately administer oral glucose (15-20g) for conscious patients who can swallow, or glucagon injection for unconscious patients, followed by calling emergency services for severe cases. 1, 2, 3

Assessment and Initial Management

Conscious Patient with Mild-Moderate Hypoglycemia

  • If patient is conscious, able to follow commands and swallow safely:
    • Administer 15-20g of fast-acting oral glucose 1, 2
    • Preferred options (in order):
      1. Glucose tablets (most effective) 1
      2. 4 oz (120 mL) of fruit juice or regular soda
      3. 1 tablespoon of honey or sugar dissolved in water
    • Recheck blood glucose after 15 minutes 1, 2
    • If blood glucose remains <70 mg/dL, repeat treatment with another 15-20g of glucose 1, 2
    • Wait at least 10-15 minutes before calling EMS or re-treating with additional oral sugars 1
    • Once blood glucose normalizes, provide a meal or snack with protein and complex carbohydrates to prevent recurrence 2

Unconscious Patient or Severe Hypoglycemia

  • If patient is unconscious, having seizures, or unable to swallow safely:
    • Call EMS immediately 1
    • Administer glucagon via injection 3:
      • Adults and children >25kg or ≥6 years: 1mg subcutaneously or intramuscularly into upper arm, thigh, or buttocks
      • Children <25kg or <6 years: 0.5mg subcutaneously or intramuscularly
      • May repeat dose after 15 minutes if no response while waiting for emergency assistance 3
    • Position patient on their side to prevent aspiration
    • Monitor vital signs until EMS arrives
    • Once patient regains consciousness and can swallow safely, provide oral carbohydrates to restore liver glycogen and prevent recurrence 3

Special Considerations

Hospital Setting

  • Implement standardized hypoglycemia protocol 2:
    • Nurse-initiated treatment protocol for blood glucose <70 mg/dL
    • Documentation of hypoglycemic episodes
    • Review of treatment regimens to prevent further episodes

Pediatric Patients

  • Children may be uncooperative with oral glucose administration
  • Consider sublingual glucose administration for uncooperative children 1
  • Children are particularly vulnerable due to reduced ability to recognize symptoms 2

Elderly Patients

  • More vulnerable to hypoglycemia due to reduced symptom recognition 2
  • May require closer monitoring and more conservative glucose targets

Follow-up Care

  • After successful treatment of hypoglycemia:
    • Identify and address the cause (medication dosing, missed meals, exercise)
    • Consider temporarily raising glycemic targets to avoid recurrence 2
    • Educate patient and family members about recognition and treatment of hypoglycemia
    • Ensure patient has glucagon emergency kit and family members know how to use it 2, 3
    • Recommend wearing medical alert identification 2

Common Pitfalls to Avoid

  1. Delayed treatment: Hypoglycemia is an emergency; treat immediately when recognized 3
  2. Inadequate monitoring: Always recheck glucose 15 minutes after treatment 1, 2
  3. Premature discharge: Ensure blood glucose has stabilized and patient has consumed a meal before leaving 4
  4. Overlooking the cause: Identify and address the underlying cause to prevent recurrence
  5. Insufficient follow-up: Less than 8% of patients treated for hypoglycemia and left at home need secondary treatment within 72 hours, but follow-up is still important 4

By following this algorithmic approach to hypoglycemia management, healthcare providers can effectively treat this common but potentially dangerous condition while minimizing complications and preventing recurrence.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Hypoglycemia Management in Diabetes

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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