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Differential Diagnosis for a 19mm Painful Nodule in the Right Femoral Lymph Node in a 4-Year-Old

Single Most Likely Diagnosis

  • Cat Scratch Disease: This is a common condition in children, caused by Bartonella henselae, typically presenting with a painful lymph node near the site of a cat scratch. The age of the patient and the description of the lymph node make this a plausible diagnosis.

Other Likely Diagnoses

  • Infectious Lymphadenitis: Bacterial or viral infections can cause lymphadenitis, which presents as a painful lymph node. Common pathogens include Staphylococcus aureus, Streptococcus pyogenes, and viral infections like influenza or adenovirus.
  • Tuberculosis: Although less common in some regions, tuberculosis (TB) can cause lymphadenitis, especially in children exposed to TB or in areas with high TB prevalence.
  • Atypical Mycobacterial Infection: Similar to TB, atypical mycobacteria can cause lymphadenitis, particularly in immunocompetent children.

Do Not Miss Diagnoses

  • Lymphoma: Although rare, lymphoma is a critical diagnosis not to miss. It can present with lymphadenopathy, and a painful lymph node, especially if it's enlarging or persistent, warrants further investigation.
  • Neuroblastoma: This is a type of cancer that can present with lymphadenopathy, among other symptoms. It's more common in younger children and can be life-threatening if not diagnosed early.
  • Histiocytosis: Langerhans cell histiocytosis can cause lymphadenopathy, bone lesions, and other systemic symptoms. It's rare but important to consider due to its potential severity.

Rare Diagnoses

  • Kikuchi-Fujimoto Disease: A rare, self-limiting condition that causes lymphadenitis, more commonly seen in Asian populations and typically in older children or young adults.
  • Kimura Disease: Another rare condition that presents with lymphadenopathy and eosinophilia, more common in Asian males.
  • Castleman Disease: A rare disorder that can cause lymphadenopathy, among other symptoms, due to overgrowth of cells in the lymph node.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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