Intrahepatic Cholestasis of Pregnancy (ICP): This condition is characterized by intense itching, particularly on the palms and soles, without a rash, and is often associated with elevated bile acids. It typically presents in the third trimester, making it a likely diagnosis at 38 weeks gestation.

Pregnancy-related Pruritus: A common condition in pregnancy, often without a specific cause, leading to generalized itching.
Dry Skin (Xerosis): Pregnancy can cause changes in skin hydration, leading to dryness and itching, especially on the arms and legs.
Allergic Contact Dermatitis: Exposure to allergens can cause an allergic reaction, leading to itching and a rash on the affected areas.
Eczema (Atopic Dermatitis): A pre-existing condition that can worsen during pregnancy, causing itching, dryness, and rash on the skin.

Cholestasis of Pregnancy with Hepatic Dysfunction: Although less common, this condition can lead to serious complications for both the mother and the fetus if not promptly diagnosed and managed.
Pemphigoid Gestationis: A rare autoimmune disease that causes blistering of the skin and intense itching, which can be harmful if not treated properly.
Obstetric Cholestasis with Coagulopathy: A condition that can lead to coagulation disorders and increase the risk of bleeding, making it crucial for early detection and management.

Polycythemia Vera: A rare blood disorder that can cause itching due to the release of histamine from basophils, although it is less commonly associated with pregnancy.
Thyroid Disorders: Both hyperthyroidism and hypothyroidism can cause skin changes and itching, though they are less directly linked to the specific symptom of itching in late pregnancy.
Systemic Lupus Erythematosus (SLE): An autoimmune disease that can cause a variety of symptoms, including skin rashes and itching, though it is not as commonly associated with itching as other symptoms.