What is the infusion rate for 2 mU/min of Pitocin (oxytocin)?

Oxytocin Infusion Rate Calculation for 2 mU/min

For an infusion rate of 2 milliunits (mU) per minute of Pitocin (oxytocin), you should prepare a solution of 10 units of oxytocin in 1000 mL of non-hydrating diluent, resulting in a concentration of 10 mU/mL, and set the infusion pump to deliver 0.2 mL/minute (12 mL/hour).

Calculation Explanation

The calculation is based on the FDA-approved drug labeling for oxytocin administration 1:

1. Standard dilution: 10 units (1 mL) of oxytocin in 1000 mL of non-hydrating diluent
2. This creates a solution with concentration of 10 mU/mL
3. To deliver 2 mU/min:
   • Flow rate = Desired dose ÷ Concentration
   • Flow rate = 2 mU/min ÷ 10 mU/mL = 0.2 mL/min
   • Converted to hourly rate: 0.2 mL/min × 60 min/hr = 12 mL/hr

Administration Guidelines

• Use an infusion pump or other such device to accurately control the rate of infusion 1
• Administer through an intravenous line for precise control
• Use physiologic electrolyte solutions as the diluent except under unusual circumstances 1
• Ensure thorough mixing by rotating the infusion bottle after adding oxytocin 1

Clinical Considerations

• For labor induction, the initial dose should be no more than 1-2 mU/min, with gradual increases in increments of no more than 1-2 mU/min until a normal labor contraction pattern is established 1
• Continuous monitoring of fetal heart rate, resting uterine tone, and the frequency, duration, and force of contractions is essential 1
• Discontinue oxytocin immediately in the event of uterine hyperactivity or fetal distress 1
• Low-dose oxytocin protocols (starting at 1-2 mU/min with increases at intervals of not less than 60 minutes) have been shown to be effective while requiring fewer adjustments for uterine hyperstimulation compared to traditional protocols 2

Safety Precautions

• Accurate control of infusion rate is essential to prevent complications 1
• Have emergency equipment readily available
• Monitor for signs of water intoxication, especially with prolonged infusion
• Be prepared to discontinue the infusion immediately if adverse effects occur

By following these guidelines, you can safely administer oxytocin at the prescribed rate of 2 mU/min.