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Differential Diagnosis for Firm, Fixed Preauricular Mass

Single Most Likely Diagnosis

  • Benign lymphoepithelial cyst: This is a common cause of a firm, fixed preauricular mass, often associated with HIV infection or other immunocompromised states. The cysts are usually painless and can be single or multiple.

Other Likely Diagnoses

  • Parotid gland tumor (benign or malignant): Tumors of the parotid gland, such as pleomorphic adenoma or adenocarcinoma, can present as a firm, fixed preauricular mass. The parotid gland is located in the preauricular area, making it a likely source of such masses.
  • First branchial cleft cyst: These congenital anomalies can present as a firm, fixed mass in the preauricular area, often becoming apparent during childhood but can also be diagnosed in adults.
  • Preauricular sinus or cyst: A congenital anomaly that can become infected and present as a firm, fixed, and possibly painful mass in the preauricular area.

Do Not Miss Diagnoses

  • Malignant lymphoma: Although less common, lymphoma involving the lymph nodes in the preauricular area can present as a firm, fixed mass. Given its potential for serious consequences, it is crucial not to miss this diagnosis.
  • Metastatic disease to the parotid gland or lymph nodes: Metastasis from other primary sites can present as a firm, fixed preauricular mass, emphasizing the importance of a thorough diagnostic workup.

Rare Diagnoses

  • Warthin's tumor: A rare, benign tumor of the salivary glands, which can present in the preauricular area, especially in older males.
  • Kimura disease: A rare, chronic inflammatory disorder that can cause lymphadenopathy and the formation of subcutaneous nodules, potentially in the preauricular area.
  • Sarcoidosis: Although rare, sarcoidosis can involve the lymph nodes and salivary glands, potentially presenting as a firm, fixed preauricular mass.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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