Primary Biliary Cholangitis (PBC): This condition is closely associated with cirrhosis and can cause pruritic skin lesions, including subcutaneous nodules. The pruritus in PBC is often severe and can precede the diagnosis of liver disease.

Nodular Prurigo: A skin condition characterized by intensely pruritic nodules, which can be associated with chronic liver disease, including cirrhosis. The exact pathogenesis is unclear, but it's thought to be related to the scratching behavior in response to pruritus.
Pruritic Nodules Associated with Cholestasis: Cholestasis, which can occur in cirrhosis, leads to the accumulation of bile salts in the skin, causing pruritus and potentially leading to the formation of pruritic nodules.
Cutaneous Mastocytosis: Although less common, mastocytosis can cause pruritic skin lesions, including nodules, and has been associated with liver disease.

Hepatocellular Carcinoma Metastases: While rare, hepatocellular carcinoma (a complication of cirrhosis) can metastasize to the skin, presenting as subcutaneous nodules. Missing this diagnosis could be fatal.
Infectious Causes (e.g., Mycobacterial or Fungal Infections): Patients with cirrhosis are immunocompromised and at higher risk for infections, including those that can cause skin nodules. These infections can be life-threatening if not promptly treated.

Nephrogenic Systemic Fibrosis (NSF): A condition associated with renal failure and exposure to certain gadolinium-based contrast agents, characterized by fibrotic skin lesions and nodules. While rare, it's a consideration in patients with cirrhosis who may have renal impairment.
Sarcoidosis: A systemic granulomatous disease that can affect the skin, causing nodules, and can also involve the liver, leading to cirrhosis in rare cases. The presence of both skin and liver involvement makes it a rare but interesting differential.