From the FDA Drug Label
Meropenem for injection is indicated for the treatment of complicated skin and skin structure infections (cSSSI) due to ... Proteus mirabilis, ... Meropenem for injection is indicated for the treatment of complicated appendicitis and peritonitis caused by ... Escherichia coli, ... Pseudomonas aeruginosa, ... and Peptostreptococcusspecies, and also for the treatment of bacterial meningitis. The clinical efficacy rates by pathogen are provided in Table 8 ... MICROORGANISMS ... Meropenem for Injection n/N (%) ... Proteus mirabilis 11/13 (85)
The recommended antibiotic treatment for Proteus mirabilis infections is meropenem.
- The dosage is 500 mg given every 8 hours for skin and skin structure infections and 1 gram given every 8 hours for intra-abdominal infections.
- Meropenem has been shown to be effective in treating Proteus mirabilis infections, with a clinical efficacy rate of 85% 1.
From the Research
Proteus mirabilis infections should be treated with piperacillin-tazobactam, carbapenems, or cephalosporins, as these antibiotics have shown the highest susceptibility levels against the bacterium, according to the most recent study 2. When considering treatment options for Proteus mirabilis infections, it is essential to prioritize antibiotics that have demonstrated high efficacy against this bacterium. The study published in 2024 2 provides the most recent and relevant evidence, indicating that piperacillin-tazobactam, carbapenems, and cephalosporins are the most effective treatment options.
Some key points to consider when treating Proteus mirabilis infections include:
- The bacterium's ability to produce urease, which can lead to stone formation and raise urine pH, making prompt and effective treatment crucial in urinary tract infections.
- The increasing resistance patterns of Proteus mirabilis, emphasizing the need for susceptibility testing to guide antibiotic selection.
- The potential for severe consequences, including fatal outcomes, in hospitalized patients with Proteus mirabilis infections, particularly those undergoing renal dialysis 2.
In terms of specific treatment regimens, the following options may be considered:
- For uncomplicated urinary tract infections, oral antibiotics such as piperacillin-tazobactam or cephalosporins may be effective.
- For more severe or complicated infections, intravenous therapy with carbapenems or cephalosporins may be necessary.
- In cases with urinary stones, surgical intervention may be necessary alongside antibiotic therapy to prevent recurrent infections.
It is essential to note that older studies, such as those published in 1976 3 and 1969 4, may not provide the most up-to-date or relevant evidence for treating Proteus mirabilis infections. Similarly, studies focused on phage therapy, such as those published in 2022 5 and 6, may offer alternative treatment approaches, but their clinical application and effectiveness are still being researched and evaluated.