From the Research
There is no direct evidence to suggest a strong relationship between hyposmia and Systemic Lupus Erythematosus (SLE) based on the provided studies, but controlling SLE activity through medications such as hydroxychloroquine, corticosteroids, or immunosuppressants may help alleviate associated symptoms, including hyposmia, by reducing inflammation 1.
Understanding Hyposmia and SLE
Hyposmia, or reduced sense of smell, can be associated with various conditions, including autoimmune diseases like SLE. However, the direct link between hyposmia and SLE is not well-established in the provided evidence.
Importance of Controlling SLE Activity
Controlling SLE activity is crucial for managing the disease and its associated symptoms. Treatment primarily focuses on controlling the underlying lupus activity through regular lupus medications, which may include hydroxychloroquine (200-400mg daily), corticosteroids like prednisone, or immunosuppressants such as mycophenolate mofetil or azathioprine, depending on the specific case 1.
Ruling Out Other Causes
It's essential to rule out other causes of reduced smell, including COVID-19, sinus infections, or medication side effects. Maintaining good overall lupus control through medication adherence, regular follow-ups with a rheumatologist, and avoiding lupus flare triggers may help improve associated symptoms, including hyposmia.
Additional Evaluations
If the smell loss is severe or persistent despite well-controlled lupus, an ENT specialist evaluation may be warranted to assess for additional contributing factors.
Key Considerations
- The provided studies do not directly address the relationship between hyposmia and SLE but emphasize the importance of controlling SLE activity and considering other potential causes of hyposmia.
- The most recent and highest quality study 1 suggests that controlling SLE activity is key to managing symptoms, which may indirectly benefit hyposmia by reducing inflammation.