What is the dosing for Minoxidil (Rogaine) 5%?

From the Guidelines

Minoxidil 5% should be dosed at 1-3 times daily, with a dose range of 5-100 mg/day, and is associated with hirsutism, requiring a loop diuretic, and can induce pericardial effusion. When considering the dosing for Minoxidil (Rogaine) 5%, it's essential to prioritize the potential side effects and interactions, as outlined in the study by 1. The study provides a comprehensive guide to the management of high blood pressure in adults, including the dosing and potential side effects of various medications, including Minoxidil.

Key Considerations

• The dose range of 5-100 mg/day should be carefully considered, taking into account the potential for sodium and water retention, as well as reflex tachycardia, which may require the use of a diuretic and beta blocker.
• The association of Minoxidil with hirsutism and the need for a loop diuretic should be carefully evaluated, particularly in patients with a history of hair growth disorders or those taking other medications that may interact with Minoxidil.
• The potential for pericardial effusion should be monitored closely, especially in patients with pre-existing heart conditions.

Administration and Monitoring

• Minoxidil should be administered orally, with the dose titrated to achieve the desired therapeutic effect, as outlined in the study by 1.
• Patients should be closely monitored for signs of side effects, including hirsutism, pericardial effusion, and sodium and water retention, and the dose adjusted accordingly.
• The use of Minoxidil should be carefully considered in patients with a history of cardiovascular disease, as the potential for adverse effects may be increased.

From the FDA Drug Label

For best results, apply 1 mL with applicator 2 times a day directly onto the scalp in the hair loss area. Apply minoxidil topical solution 5% once in the morning and once at night. The nighttime application should occur 2 to 4 hours before going to bed to allow for drying.

The dosing for Minoxidil (Rogaine) 5% is 1 mL, twice a day, applied directly to the scalp in the hair loss area, once in the morning and once at night, with the nighttime application allowing 2 to 4 hours for drying before going to bed 2.

From the Research

Dosing for Minoxidil (Rogaine) 5%

• The dosing for Minoxidil (Rogaine) 5% is typically applied twice daily 3, 4, 5
• One study used a 5% minoxidil topical foam applied once daily 6
• Another study compared the efficacy of 5% minoxidil applied twice daily to a combined solution of 5% minoxidil and 0.01% tretinoin applied once daily, with no significant difference in efficacy between the two groups 4
• The recommended dosage for male pattern hair loss is 5% minoxidil topical solution or foam applied twice daily 5

Application and Administration

• The solution or foam should be applied directly to the scalp, typically in the morning and evening 3, 4, 5
• One capful (1 ml) of minoxidil 5% topical foam is usually applied daily 6

Special Considerations

• Patients who are non-responders to 5% minoxidil may benefit from a higher dosage, such as 15% topical minoxidil solution 7
• However, the safety and efficacy of higher dosages have not been extensively studied, and patients should consult with their healthcare provider before using any medication 7