From the FDA Drug Label
For best results, apply 1 mL with applicator 2 times a day directly onto the scalp in the hair loss area. Apply minoxidil topical solution 5% once in the morning and once at night. The nighttime application should occur 2 to 4 hours before going to bed to allow for drying.
The dosing for Rogaine (Minoxidil) 5% topical solution is 1 mL, twice a day, applied directly to the scalp in the hair loss area. The application should be done once in the morning and once at night, with the nighttime application allowing for 2 to 4 hours of drying time before going to bed 1.
From the Research
Rogaine 5% topical solution (minoxidil) should be applied twice daily, using 1 ml per application to the affected areas of the scalp, as this dosing regimen has been shown to be effective in promoting hair growth and reducing hair loss in patients with androgenetic alopecia 2.
Key Considerations
- The total daily dose should not exceed 2 ml to minimize the risk of side effects.
- Apply to dry scalp and hair, spreading it evenly with fingertips and washing hands thoroughly afterward to prevent unwanted hair growth on other parts of the body.
- Allow the solution to dry completely before using other hair products or going to bed to ensure optimal absorption and effectiveness.
Mechanism of Action and Efficacy
- Minoxidil works by prolonging the growth phase of hair follicles and increasing follicle size, though the exact mechanism isn't fully understood 3, 4, 5.
- Consistent application is essential for effectiveness, and results typically take 4-6 months to become noticeable 6.
- If treatment is discontinued, any new hair growth will likely be lost, highlighting the importance of long-term adherence to the treatment regimen.
Safety and Side Effects
- Side effects may include scalp irritation, unwanted hair growth elsewhere on the body if the solution drips, and rarely, changes in blood pressure 3, 4, 5.
- If severe scalp irritation occurs, discontinue use and consult a healthcare provider to determine the best course of action.
Comparison with Other Treatments
- The association of 5% minoxidil with other treatments, such as topical finasteride, may show improved clinical efficacy compared to monotherapy 2.
- However, the current evidence supports the use of 5% minoxidil as a standalone treatment for androgenetic alopecia, with a well-established safety and efficacy profile 3, 4, 5, 6.