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Differential Diagnosis for a 39-year-old Female with a Small, Lovable Mass in her Right Axillae

  • Single Most Likely Diagnosis
    • Lipoma: A benign tumor composed of fat tissue, which is often soft, movable, and painless, fitting the description of a "lovable mass."
  • Other Likely Diagnoses
    • Cyst (e.g., sebaceous cyst): These are common, benign lesions that can occur in the axilla and may present as a small, movable mass.
    • Lymphadenopathy (reactive or infectious): Enlarged lymph nodes in the axilla can be due to a variety of causes, including infections or reactions to irritants, and might feel like a small mass.
    • Fibroadenoma (ectopic breast tissue): Although less common in the axilla, ectopic breast tissue can develop fibroadenomas, which are benign tumors that can feel like a small, movable mass.
  • Do Not Miss Diagnoses
    • Breast cancer (metastatic to axillary lymph nodes): Although less likely, it is crucial to consider breast cancer, especially if the mass is hard, fixed, or accompanied by other symptoms like nipple discharge or a breast lump.
    • Lymphoma: Enlarged lymph nodes in the axilla can be a sign of lymphoma, a type of blood cancer, which requires prompt diagnosis and treatment.
    • Soft tissue sarcoma: Although rare, sarcomas can occur in the axilla and may present as a growing mass, making early detection critical.
  • Rare Diagnoses
    • Neurofibroma: A benign nerve sheath tumor that can occur in the axilla, often associated with neurofibromatosis type 1.
    • Dermatofibrosarcoma protuberans: A rare skin cancer that can present as a firm mass in the axilla or other areas.
    • Metastatic disease to the axilla from other primary sites: Rarely, cancers from other parts of the body can metastasize to the axillary lymph nodes, presenting as a mass.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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