What is the difference between petrolatum and Aquaphor (petrolatum)?

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Last updated: February 9, 2025 • View editorial policy

From the Research

Difference between Petrolatum and Aquaphor

  • Petrolatum, also known as Vaseline or white petrolatum, is a petroleum-based moisturizer that is often used to suppress water evaporation from the skin surface 1, 2.
  • Aquaphor, on the other hand, is a petrolatum-based ointment that is designed to provide long-lasting moisturization and protection for dry, cracked, or irritated skin 3, 4.

Key Differences

  • A study compared the effectiveness and usability of a newly developed petrolatum-based ointment (NOV® II Moisture Balm) with white petrolatum, and found that the petrolatum-based ointment had superior usability, with subjects feeling that it spread better and was less sticky and shiny than white petrolatum 1.
  • Another study found that Aquaphor Healing Ointment, a petrolatum-based ointment, provided equivalent efficacy for wound healing as a combination antibiotic first-aid ointment, and had fewer adverse effects 3.
  • However, a study comparing Aquaphor with onion extract gel found no statistically significant difference between the two treatments in improving the appearance and symptoms of new surgical scars 4.
  • A comparison of two commonly used petrolatum-based ointments, Aquaphor Healing Ointment and white petroleum jelly, found that surgical wounds treated with Aquaphor had a higher incidence of wound redness than those treated with plain white petrolatum 5.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.