From the Guidelines
Lactulose and polyethylene glycol–based laxatives are safe for pregnant patients with constipation.
Treatment Options
- Dietary fiber intake is recommended to promote regular bowel movements and prevent constipation, with a daily amount of approximately 30 g/d of fruits, vegetables, whole grains, and legumes 1.
- Bulk-forming agents, such as psyllium husk or methylcellulose, are safe to administer in pregnancy due to the lack of systemic absorption 1.
- Osmotic laxatives, such as polyethylene glycol or lactulose, can also be administered safely during pregnancy, but may cause maternal bloating 1.
Laxatives to Avoid
- Stimulant laxatives should be avoided because safety data on these medications are conflicting 1.
Additional Recommendations
- Encouraging pregnant women to avoid straining during bowel movements by providing ample time, using relaxation techniques, and adjusting diet and hydration is helpful 1.
- Consumption of an adequate amount of fluids, particularly water, can help soften stools and ease bowel movements 1.
From the Research
Safe Laxatives for Pregnant Patients with Constipation
- Natural fibres (bulk-forming agents), docusate sodium (stool-softener), mineral oils (lubricant laxatives), macrogol (polyethylene glycol, PEG), sugars and sugar alcohols (osmotic laxatives) and anthraquinones and diphenolic laxatives (stimulant laxatives) seem to be safe medicaments regarding teratogenicity and lactation 2
- Macrogol and lactulose are suggested as the first-line therapy in treating chronic constipation during pregnancy, with macrogol showing some advantages such as faster onset of bowel action and fewer flatulences 2
- Diphenolic laxatives such as bisacodyl and sodium picosulfate are recommended as a second-line treatment in the second and third trimester 2
- Fibre supplements, such as bran or wheat fibre, are likely to help women experiencing constipation in pregnancy, and stimulant laxatives may be more effective than bulk-forming laxatives but may cause more side effects 3, 4
- Osmotic laxatives, such as polyethylene glycol, may be beneficial for some patients, and the short-term use of osmotic or stimulant laxatives is generally reserved for patients who fail to respond to dietary changes or bulking agents 5
Comparison of Laxatives
- Stimulant laxatives versus bulk-forming laxatives: stimulant laxatives appear to be more effective in improvement of constipation, but are accompanied by an increase in diarrhoea and abdominal discomfort 3
- Fibre supplementation versus no intervention: fibre supplementation may increase frequency of stools compared with no intervention 3