From the Guidelines
The loading dose of Fasenra (Benralizumab) should be repeated upon restarting administration of the medication if the patient is flaring and/or if more than 3-4 half-lives have passed since the previous dose. When considering the management of missed doses of Fasenra, it's crucial to assess the disease severity and the number of doses missed, as these factors influence the decision to repeat the loading dose 1. The guidelines suggest that the necessity of repeating the loading doses depends on these factors, and it's recommended to consider repeating the loading dose if the patient is experiencing a flare or if a significant amount of time has passed since the last dose 1. Key points to consider when deciding on the loading dose include:
- Disease severity
- Number of doses missed
- Time elapsed since the last dose
- Presence of flare It's essential to consult with a healthcare professional before restarting therapy after missed doses, as they can provide personalized guidance based on the patient's specific clinical situation 1. In clinical practice, the decision to repeat the loading dose should prioritize maintaining therapeutic drug levels to effectively manage the condition, while also considering the potential risks and benefits of restarting therapy 1.
From the Research
Loading Dose of Fasenra (Benralizumab) After Missed Doses
There are no research papers to assist in answering this question, as the provided studies do not mention Fasenra (Benralizumab) or its loading dose after missed doses.
General Information on Missed Doses
- The provided studies discuss the importance of handling delayed or missed doses in various medications, including valproic acid 2, lamotrigine 3, and other prescription-only medicines 4, 5, 6.
- These studies highlight the need for clear guidance on managing missed doses to minimize unintended clinical consequences.
- However, none of the studies provide information on Fasenra (Benralizumab) or its specific dosing recommendations after missed doses.