What are the patient instructions for taking sildenafil (Viagra)?

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Patient Instructions for Taking Sildenafil (Viagra)

Sildenafil should be taken approximately 30-60 minutes before sexual activity, with or without food, though high-fat meals may delay onset of action. 1, 2

Dosing Information

  • Starting dose:

    • For erectile dysfunction: 50 mg as needed (can be adjusted to 25-100 mg based on efficacy and tolerability) 3
    • For pulmonary arterial hypertension: 20 mg three times daily, taken 4-6 hours apart 1
  • Timing considerations:

    • Take 30-60 minutes before anticipated sexual activity 2
    • Effects can last up to 4 hours, though may remain effective for up to 10 hours 2
    • Can be taken with or without food, though high-fat meals may delay onset of action 2

Important Safety Warnings

  • Absolute contraindication: Do not take with nitrate medications (including nitroglycerin in any form, isosorbide mononitrate/dinitrate, or "poppers") due to risk of severe, potentially fatal hypotension 4, 1

    • If taking sildenafil, avoid nitrates for at least 24 hours 4
    • If emergency nitrate administration is needed, it must be done under close medical supervision 4
  • Cardiovascular considerations:

    • Use caution if you have unstable angina, recent heart attack or stroke, cardiac failure, uncontrolled hypertension, or impaired cardiac reserve 3
    • Report any chest pain, severe dizziness, or fainting to your doctor immediately 1

Common Side Effects

  • Headache, flushing, upset stomach, nasal congestion
  • Visual disturbances (temporary blue tinge to vision)
  • Dizziness, back pain, muscle pain 3, 1

Special Instructions

  • For optimal effectiveness:

    • Ensure adequate sexual stimulation, as sildenafil will not work without it 4, 3
    • Allow sufficient time for onset of action (30-60 minutes) 2
    • If first attempt is unsuccessful, try again on different occasions before concluding it doesn't work 4
  • Dose adjustments:

    • If experiencing side effects with 50 mg, consider reducing to 25 mg
    • If 50 mg is insufficient, may increase to 100 mg with doctor's approval 3, 1
    • Elderly patients (>65 years) or those with liver/kidney impairment may need to start with 25 mg 5

When to Contact Your Doctor

  • If you experience an erection lasting more than 4 hours (priapism) - this requires immediate medical attention 1
  • Sudden decrease or loss of vision or hearing 1
  • If medication doesn't work after several attempts with proper usage 4
  • Before taking any new medications, as interactions may occur 1

Follow-up Care

  • Regular follow-up with your doctor is recommended to assess efficacy, side effects, and any changes in health status or medications 4

Remember that erectile dysfunction may be a sign of underlying cardiovascular disease, so appropriate medical evaluation is important 3.

References

Guideline

Cardiovascular Risks of Concomitant Medication Use

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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