Peripheral Artery Disease (PAD): This condition is characterized by the narrowing or blockage of the blood vessels outside of the heart, leading to reduced blood flow to the limbs. The pain and burning sensation in the lower extremities, especially with rest, are classic symptoms of PAD, often referred to as rest pain. It typically occurs in patients with a history of smoking, diabetes, high blood pressure, or high cholesterol.

Diabetic Neuropathy: A common complication of diabetes, causing damage to the peripheral nerves, which can lead to pain, burning, and numbness in the feet and legs. The symptoms can be exacerbated by rest.
Chronic Venous Insufficiency: This condition occurs when the veins have problems returning blood from the legs back to the heart due to issues like blood clots or varicose veins. It can cause pain, swelling, and a burning sensation in the legs, which may worsen with rest.
Musculoskeletal Issues: Conditions such as muscle strain, tendonitis, or bursitis can cause pain and burning sensations in the lower extremities. While these are more commonly associated with activity, certain positions or prolonged rest can exacerbate the symptoms.

Deep Vein Thrombosis (DVT): A blood clot that forms in a vein deep inside your body, typically in the legs. DVT can cause pain, swelling, and warmth in the affected leg, and it is crucial to diagnose promptly due to the risk of pulmonary embolism.
Compartment Syndrome: A condition where pressure within the muscles builds to dangerous levels, decreasing blood flow and potentially leading to nerve damage. It is a medical emergency that requires immediate attention.
Aortic Occlusion: A blockage of the aorta, which can lead to severe pain in the lower back and legs, especially with rest. It is a life-threatening condition that requires immediate medical intervention.

Erythromelalgia: A rare disorder characterized by burning pain, heat, and redness in the hands and feet. It can be primary (genetic) or secondary to other conditions like myeloproliferative disorders.
Complex Regional Pain Syndrome (CRPS): A chronic pain condition that most often affects one of the arms, legs, hands, or feet after an injury or trauma. It is characterized by intense burning or aching pain in the affected limb.
Peripheral Neuropathy due to Vitamin Deficiency: Deficiencies in vitamins like B12 can lead to peripheral neuropathy, causing pain, numbness, and burning sensations in the feet and legs.