From the Research
Definition and Composition of Semax (Selank) Nasal Spray
- Semax is a synthetic analog of adrenocorticotropic hormone 4-10 with a pronounced nootropic effect 1, 2.
- It is a heptapeptide that stimulates memory and attention in rodents and humans after intranasal application 3.
Mechanism of Action and Effects
- Semax has been shown to stimulate operative memory and attention, increase resistance to hypoxia, and improve brain circulation in experimental animals and human beings 1.
- It can augment the effects of psychostimulants on central dopamine release and stimulate central brain-derived neurotrophic factor (BDNF) synthesis 3.
- Semax has been found to have anxiolytic and antidepressant effects, possibly due to the activation of the brain serotoninergic system and increased BDNF expression in the rat hippocampus 4.
Therapeutic Applications
- Semax is used in the treatment of patients with different diseases of the central nervous system (CNS) 1.
- It has been proposed as a potential agent for the treatment of attention-deficit hyperactivity disorder (ADHD) and Rett syndrome due to its ability to improve selective attention and modulate brain development 3.
- Semax has been used to treat vascular, toxic allergic, and inflammatory diseases of the optic nerve and partial atrophy of the optic nerve, with favorable results 2.
- The peptide has also been investigated for its effects on behavior in rats with 6-OHDA induced PD-like parkinsonism, with Selank (an analog of immunomodulatory taftsin) decreasing the level of anxiety in rats with toxic damage of DA neurons 5.