What is the treatment for a spider bite?

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Last updated: March 8, 2025 • View editorial policy

From the Guidelines

For a spider bite, the most effective treatment involves cleaning the area with soap and water, applying an ice pack to reduce pain and swelling, and taking over-the-counter pain relievers like acetaminophen or ibuprofen as needed, as recommended by the 2024 American Heart Association and American Red Cross guidelines for first aid 1, 2. When it comes to treating spider bites, it's essential to prioritize wound care and pain management.

  • Clean the affected area with soap and water to prevent infection.
  • Apply an ice pack to reduce pain and swelling, as suggested by the guidelines 2.
  • Take over-the-counter pain relievers like acetaminophen (Tylenol) or ibuprofen (Advil) as needed to alleviate local pain.
  • Elevate the affected limb if possible to reduce swelling.
  • Apply an antibiotic ointment like Neosporin to prevent infection, although this is not explicitly mentioned in the guidelines, it is a common practice in wound care. Most spider bites heal on their own within a week, but it's crucial to monitor the bite and seek medical attention if symptoms worsen or if you suspect a black widow or brown recluse spider bite, as these may require antivenin treatment 1.
  • Seek immediate medical attention if you develop symptoms like severe pain, increasing swelling, difficulty breathing, or signs of infection such as warmth, pus, or fever, as recommended by the guidelines 2.
  • Emergency services should be called if a person bitten by a spider develops symptoms throughout the body, such as difficulty breathing, muscle rigidity, dizziness, or confusion, as stated in the guidelines 2.

From the Research

Treatment Options for Spider Bites

  • The treatment for spider bites varies depending on the type of spider and the severity of the bite.
  • For brown recluse spider bites, a simple technique of curetting the subcutaneous tissue in the necrotic area of the lesion can be effective in preventing skin necrosis and the need for reconstructive surgery 3.
  • This technique can be performed as an outpatient procedure under local anesthesia, and it has been shown to control symptoms and prevent further necrosis with excellent cosmetic results 3.
  • For black widow spider bites, antivenom is considered the most efficacious therapy available, with opioid analgesics and muscle relaxants providing only temporary and symptomatic relief 4, 5.
  • In some cases, surgical treatment may be necessary, such as in the case of a brown recluse spider bite that is refractory to conservative treatment 6.
  • For other types of spider bites, such as those from the running spider (Philodromus sp.), management should be as recommended for other cytotoxic spider bites 7.

Symptomatic Relief

  • Muscle relaxants, such as benzodiazepines, can be used to provide symptomatic relief for black widow spider bites 4, 5.
  • Calcium gluconate can also be used to provide relief from muscle spasms and pain 5.
  • Opioid analgesics can be used to manage pain, but they are only effective for temporary and symptomatic relief 4.

Prevention of Complications

  • It is essential to minimize inflammation and tissue necrosis, prevent bacterial superinfection, and control pain levels to prevent long-term complications such as peripheral neuropathy 6.
  • Antivenom can be used to prevent severe envenomation and reduce the risk of respiratory failure and coma 5.

References

Research

Management of the brown recluse spider bite.

Journal of pediatric surgery, 1989

Research

Black widow spider (Latrodectus mactans) antivenom in clinical practice.

Current pharmaceutical biotechnology, 2012

Research

Black widow spider bite.

American family physician, 1984

Research

Surgical treatment of a brown recluse spider bite: a case study and literature review.

The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons, 2014

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.