What is the differential diagnosis for a flesh-colored, soft, non-tender, mobile nodule (mass) on the left knee of a 6-year-old female?

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Differential Diagnosis for Flesh Colored, Soft, Nontender, Mobile Nodule on Left Knee of 6 Year Old Girl

  • Single Most Likely Diagnosis
    • Benign fatty tumor (lipoma): This is a common, benign growth of fat cells that can occur anywhere on the body, including the knee. It is typically soft, mobile, and nontender, which matches the description provided.
  • Other Likely Diagnoses
    • Epidermal inclusion cyst: These are benign cysts that can form when skin cells are trapped beneath the skin surface. They are often flesh-colored, soft, and mobile.
    • Dermatofibroma: A benign skin growth that can appear as a firm, flesh-colored nodule. While they can be tender, especially if irritated, they are often nontender and mobile.
    • Wart: Certain types of warts, especially those caused by human papillomavirus (HPV), can appear as flesh-colored, soft nodules. However, they are typically more rough in texture and may be tender.
  • Do Not Miss Diagnoses
    • Rhabdomyosarcoma: Although rare, this is a type of soft tissue cancer that can present as a soft, mobile mass. It's crucial to consider this diagnosis to ensure timely treatment if present.
    • Neurofibroma: Part of neurofibromatosis type 1 (NF1), these tumors can be soft and mobile. Early diagnosis of NF1 is important for managing potential complications.
  • Rare Diagnoses
    • Fibroma: A rare, benign tumor of fibrous tissue that can appear as a soft, mobile nodule.
    • Myxoma: A rare, benign tumor of connective tissue that can present similarly to a lipoma but is less common.
    • Granuloma: Certain types of granulomas, such as those associated with infections or foreign body reactions, can appear as soft, flesh-colored nodules, although they are less likely in this context.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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