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Last updated: August 18, 2025View editorial policy

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Differential Diagnosis for D5 NS

  • Single most likely diagnosis
    • Hypoglycemia: The most common reason for ordering D5 NS (5% dextrose in normal saline) is to treat or prevent hypoglycemia, especially in patients who are unable to take glucose orally.
  • Other Likely diagnoses
    • Dehydration: D5 NS can be used to provide hydration and electrolytes, making dehydration another likely diagnosis.
    • Hyperkalemia: Although not the primary treatment, D5 NS can be part of the management strategy for hyperkalemia by helping to dilute potassium levels.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Diabetic ketoacidosis (DKA): In the context of administering D5 NS, it's crucial not to miss DKA, as the treatment involves careful management of fluids and electrolytes, and incorrect management can be fatal.
    • Septic shock: Patients in septic shock may require large volumes of fluid resuscitation, which could include D5 NS as part of the treatment to maintain blood pressure and perfusion of vital organs.
  • Rare diagnoses
    • Adrenal insufficiency: Although rare, adrenal insufficiency can lead to hypoglycemia and dehydration, conditions for which D5 NS might be administered.
    • Postoperative hypoglycemia: In post-surgical patients, especially those who have undergone procedures that affect glucose metabolism or have been fasting, D5 NS might be used to prevent or treat hypoglycemia.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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