What is the differential diagnosis of chronic vomiting and diarrhea?

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Differential Diagnosis for Chronic Vomiting and Diarrhea

Single Most Likely Diagnosis

  • Gastroenteritis: This is often the most common cause of chronic vomiting and diarrhea, typically resulting from a viral or bacterial infection. The chronic nature could be due to a prolonged infection or a complication such as a persistent infection or post-infectious irritable bowel syndrome (IBS).

Other Likely Diagnoses

  • Irritable Bowel Syndrome (IBS): A common condition characterized by abdominal pain, bloating, and changes in bowel movements, which can include chronic diarrhea and occasional vomiting.
  • Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease and ulcerative colitis can cause chronic diarrhea, vomiting, and abdominal pain due to inflammation in the gastrointestinal tract.
  • Gastroesophageal Reflux Disease (GERD): While primarily causing heartburn, severe GERD can lead to vomiting, and in some cases, diarrhea, especially if there's an associated condition like gastroparesis.
  • Food Intolerances or Allergies: Conditions such as lactose intolerance, gluten intolerance (celiac disease), or food allergies can cause chronic gastrointestinal symptoms including vomiting and diarrhea.

Do Not Miss Diagnoses

  • Intestinal Obstruction: Though less common, an obstruction in the intestine can cause severe vomiting and diarrhea, especially if the obstruction is partial. This condition requires immediate medical attention.
  • Gastrointestinal Cancer: Though rare, cancers of the stomach, small intestine, or colon can present with chronic vomiting and diarrhea among other symptoms.
  • Neuroendocrine Tumors: Certain tumors like gastrinomas or VIPomas can cause severe, chronic diarrhea and vomiting due to excessive hormone production.
  • Addison's Disease: A rare endocrine disorder where the adrenal glands do not produce enough cortisol and aldosterone, leading to gastrointestinal symptoms among others.

Rare Diagnoses

  • Whipple's Disease: A rare, systemic bacterial infection that can cause chronic diarrhea, vomiting, and malabsorption.
  • Eosinophilic Gastroenteritis: A condition characterized by eosinophilic infiltration of the gastrointestinal tract, leading to chronic gastrointestinal symptoms.
  • Short Bowel Syndrome: A condition that results from a significant loss of intestinal tissue, leading to malabsorption and chronic diarrhea.
  • Congenital Anomalies: Certain congenital conditions of the gastrointestinal tract, though typically diagnosed in infancy, can occasionally present later in life with chronic symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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