How to Use the Medrol Dose Package
The Medrol (methylprednisolone) dose package should be taken exactly as prescribed, with the typical regimen being a 6-day tapered course starting with 6 tablets (24 mg) on day 1, then decreasing by 1 tablet each day until completion. 1
Proper Administration Instructions
Take the medication orally with food or milk to reduce stomach irritation
Follow the specific dosing schedule printed on the package:
- Day 1: Take 6 tablets (24 mg) - all at once in the morning
- Day 2: Take 5 tablets (20 mg) - all at once in the morning
- Day 3: Take 4 tablets (16 mg) - all at once in the morning
- Day 4: Take 3 tablets (12 mg) - all at once in the morning
- Day 5: Take 2 tablets (8 mg) - all at once in the morning
- Day 6: Take 1 tablet (4 mg) - in the morning
- Day 7: No medication
Take the full daily dose in the morning (before 9 am) rather than splitting it throughout the day, as this better mimics natural cortisol production
Important Considerations
Timing of Doses
- Take the medication at the same time each day
- Morning administration (before 9 am) is preferred to minimize disruption of your body's natural cortisol rhythm
- Do not abruptly stop taking the medication before completing the full course
Potential Side Effects to Monitor
- Short-term use may cause:
- Increased blood glucose levels (especially in diabetic patients)
- Fluid retention
- Mood changes
- Sleep disturbances
- Increased appetite
Precautions
- Inform your healthcare provider about all medications you're taking
- If you miss a dose, take it as soon as you remember on the same day; do not double up doses
- Do not take more tablets than prescribed for each day
- Complete the entire course as prescribed, even if symptoms improve before finishing
Common Clinical Applications
Medrol dose packages are commonly prescribed for:
- Acute inflammatory conditions
- Allergic reactions
- Asthma exacerbations
- Dermatological conditions
- Rheumatologic disorders
Special Situations
For specific conditions, dosing may vary:
- For multiple sclerosis exacerbations: Higher doses may be used (200 mg prednisolone equivalent daily for a week followed by 80 mg every other day for a month) 1
- For asthma exacerbations: Typical outpatient "burst" is 40-60 mg in single or 2 divided doses for 5-10 days in adults 2
- For sudden hearing loss: Full dose for 7-14 days, then taper over a similar time period 2
Remember that the standard Medrol dose pack provides a total dose of 84 mg over 6 days, which may be insufficient for certain conditions requiring higher cumulative doses. Your healthcare provider will determine if the standard dose package is appropriate for your specific condition.