Which nerve root is addressed by an L4/L5 subpedicular transforaminal epidural steroid injection (ESI)?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: March 8, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

A L4/5 subpedicular transforaminal epidural steroid injection primarily addresses the L5 nerve root. This is because the nerve root exits below the corresponding vertebral level, meaning the L5 nerve root exits through the L4/5 neural foramen. When performing this injection, the needle is placed in the superior and anterior aspect of the foramen (subpedicular approach) to deliver anti-inflammatory medication directly to the affected nerve root. The medication typically includes a long-acting corticosteroid (such as dexamethasone 10mg, betamethasone 6-12mg, or methylprednisolone 40-80mg) mixed with a small amount of local anesthetic (like lidocaine 1% or bupivacaine 0.25%) 1. This approach is particularly effective because it delivers the medication directly to the site of inflammation where the nerve root may be compressed or irritated, often by a herniated disc or foraminal stenosis. The steroid reduces inflammation while the local anesthetic provides immediate pain relief and helps confirm proper medication placement. Understanding this anatomical relationship is crucial for proper needle placement and effective treatment of radicular pain originating from the L5 nerve root. Some key points to consider when performing this procedure include:

  • The use of image guidance to ensure accurate needle placement and minimize the risk of complications 2
  • The selection of the appropriate approach, such as the subpedicular or retrodiscal approach, based on the individual patient's anatomy and pathology 1
  • The importance of monitoring the patient's response to the injection and adjusting the treatment plan as needed 3
  • The potential benefits and risks of using particulate versus non-particulate steroids in transforaminal epidural injections 2

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.