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Last updated: August 18, 2025View editorial policy

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Differential Diagnosis for Swollen and Itching Foreskin

Single Most Likely Diagnosis

  • Balanitis: This is an inflammation of the glans penis and is the most common cause of a swollen and itching foreskin. It can be caused by poor hygiene, infections (bacterial, fungal, or viral), or allergic reactions.

Other Likely Diagnoses

  • Contact Dermatitis: An allergic reaction or irritation from soaps, condoms, or other products can cause itching and swelling of the foreskin.
  • Phimosis: A condition where the foreskin cannot be fully retracted over the glans, which can lead to swelling and itching due to trapped moisture and bacteria.
  • Yeast Infection (Candidiasis): A fungal infection that thrives in moist environments, such as under the foreskin, causing itching, redness, and swelling.
  • Sexually Transmitted Infections (STIs): Certain STIs like gonorrhea, chlamydia, or herpes can cause symptoms of itching and swelling in the genital area, including the foreskin.

Do Not Miss Diagnoses

  • Paraphimosis: A medical emergency where the foreskin is retracted behind the glans and cannot be returned to its original position, cutting off blood flow. It requires immediate attention to prevent serious complications.
  • Necrotizing Fasciitis: A rare but life-threatening bacterial infection that can cause rapid progression of swelling, pain, and necrosis of the skin and underlying tissues.

Rare Diagnoses

  • Lichen Sclerosus: A chronic skin condition that can cause thinning and tightening of the skin, leading to itching and swelling, particularly in the genital area.
  • Squamous Cell Carcinoma: A type of skin cancer that can present with itching, swelling, and changes in the skin of the foreskin, though it is very rare.
  • Fixed Drug Eruption: A rare condition where certain medications cause skin lesions, including on the foreskin, which can be itchy and swollen.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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