Key Aspects of Computed Tomography (CT)
Computed tomography (CT) is an ionizing cross-sectional imaging modality that uses x-rays to create three-dimensional images of the body, reflecting variations in tissue density and providing detailed visualization of internal structures. 1
Basic Principles and Technology
- CT uses x-ray technology with transmission of multiple x-ray beams through the body at diverse angles to create cross-sectional images 1
- The CT machine typically appears as a large donut-shaped structure that patients pass through during scanning 1
- Unlike conventional x-rays, CT provides detailed cross-sectional visualization of tissues and organs
- A standard CT scan delivers radiation equivalent to approximately 150 chest x-rays 1
Types of CT Scans
Standard CT
- Creates detailed cross-sectional images showing both soft tissues and bones
- May be performed with or without contrast enhancement
Low-Dose CT
- Uses lowered settings for the X-ray tube's voltage and/or current
- Primarily used for attenuation correction and anatomical localization
- Not designed for in-depth radiological analysis 1
Diagnostic CT
- Involves higher X-ray doses than low-dose CT
- May utilize oral or intravenous contrast
- Should be conducted according to local consensus protocols or established national guidelines 1
CT Angiography (CTA)
- Specialized CT acquisition timed to coincide with peak arterial or venous enhancement
- Requires three essential elements: precise timing, reconstructions/reformats, and 3D renderings
- Allows accurate delineation of vascular structures, size, and extent of aneurysms 1
Advanced CT Technologies
Dual-Energy CT
- Employs two distinct energy levels to distinguish tissues with similar densities
- Particularly beneficial in vascular imaging, oncology, and musculoskeletal assessments 1
Micro-CT
- Provides ultra-high resolution imaging at the micron scale
- Primarily used for small animal imaging and pre-clinical studies
- Allows detailed visualization of anatomical and pathological features at microscopic scale 1
Cone Beam CT (CBCT)
- Features compact design and lower radiation dose compared to conventional CT
- Primarily used in dental and maxillofacial imaging 1
Clinical Applications
Diagnostic Imaging
- Provides detailed visualization of internal structures for disease detection and characterization
- Allows for measurement of exact tumor volumes 1
Hybrid Imaging
- PET/CT combines metabolic information from PET with anatomical details from CT
- Significantly improves detection, characterization, and staging compared to other imaging modalities 2
- Particularly valuable in oncology for tumor detection and staging
Interventional Planning
- Assists in planning surgical or endovascular interventions
- Allows for accurate measurements and 3D reconstructions 1
Patient Considerations
Preparation and Procedure
- Typically brief scan (3-5 minutes for standard CT)
- Patients with claustrophobia generally experience minimal anxiety during CT scans 1
- May require contrast administration through IV for enhanced visualization
Contrast Use
- Iodine-based contrast agents may be administered orally, intraperitoneally, or intravenously
- Allows visualization of structures through negative or positive contrast 1
- Risks include contrast allergy and discomfort with IV placement 1
Technological Advancements
- Modern CT systems include dose optimization features to reduce radiation exposure 3
- Advanced post-processing techniques allow for 3D reconstructions and detailed analysis
- Emerging technologies include photon counting detectors, powerful x-ray tubes for low-kV scanning, and machine learning algorithms for image processing 4
Limitations and Considerations
- Radiation exposure remains a concern, particularly with repeated examinations
- May not provide optimal soft tissue contrast compared to MRI
- Some patients may have contraindications to contrast agents
CT technology continues to evolve rapidly, with ongoing improvements in image quality, scanning speed, and radiation dose reduction, maintaining its position as an essential diagnostic tool in modern medicine.