Gastroesophageal Reflux Disease (GERD): This is often the most common cause of non-cardiac chest pain. Symptoms can mimic cardiac issues, such as chest tightness or burning, especially after eating or at night.

Musculoskeletal Pain: Strains or inflammation in the muscles or joints of the chest wall can cause sharp pains or aching, especially with movement or deep breathing.
Respiratory Issues: Conditions like pneumonia, bronchitis, or asthma can cause chest pain due to inflammation or irritation of the lungs or airways.
Esophageal Spasm: Abnormal contractions of the esophagus can cause severe, intermittent chest pain that may be mistaken for cardiac pain.
Peptic Ulcer Disease: Ulcers in the stomach or duodenum can cause burning chest pain, especially after eating.

Pulmonary Embolism: Although less common, a blood clot in the lungs can cause sudden, severe chest pain, often accompanied by shortness of breath or coughing. Missing this diagnosis can be fatal.
Aortic Dissection: A tear in the aorta's lining can cause severe, tearing chest pain that radiates to the back. This is a medical emergency.
Pneumothorax: Air in the space between the lungs and chest wall can cause sudden chest pain and shortness of breath, requiring immediate medical attention.

Esophageal Rupture: A tear in the esophagus can cause severe chest pain, often after forceful vomiting or swallowing a large piece of food.
Pancreatitis: Inflammation of the pancreas can cause upper abdominal pain that radiates to the chest.
Costochondritis (Tietze's Syndrome): Inflammation of the cartilage that connects the ribs to the breastbone can cause sharp pains or aching in the chest wall.
Herpes Zoster (Shingles): Reactivation of the varicella-zoster virus can cause a painful rash on the chest, which may precede the rash by several days.