What is the cause of abdominal pain?

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Last updated: March 9, 2025 • View editorial policy

Differential Diagnosis for Abdominal Pain

Abdominal pain is a symptom that can be caused by a wide range of conditions, from mild to life-threatening. The differential diagnosis can be organized into the following categories:

  • Single Most Likely Diagnosis + Gastroenteritis: This is often the most common cause of abdominal pain, especially if the pain is accompanied by symptoms like diarrhea, vomiting, and fever. It's usually caused by a viral or bacterial infection.
  • Other Likely Diagnoses + Irritable Bowel Syndrome (IBS): A chronic condition characterized by abdominal pain, bloating, and changes in bowel movements. It's a common cause of abdominal pain in the absence of other alarming symptoms. + Constipation: Can cause significant abdominal pain, especially if it's severe or chronic. + Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease and ulcerative colitis can cause chronic abdominal pain, diarrhea, weight loss, and sometimes blood in the stool. + Peptic Ulcer Disease: Ulcers in the stomach or duodenum can cause abdominal pain, especially in the upper abdomen, and can be exacerbated by food or antacids.
  • Do Not Miss Diagnoses + Appendicitis: Although not the most common cause, appendicitis is a medical emergency that requires prompt surgical intervention. It typically presents with severe abdominal pain that initially might be diffuse but often localizes to the right lower quadrant. + Ectopic Pregnancy: A pregnancy that develops outside the uterus can cause severe abdominal pain and vaginal bleeding. It's a life-threatening condition that requires immediate medical attention. + Ruptured Aortic Aneurysm: A tear in the aorta can cause sudden, severe abdominal pain and is a medical emergency. + Intestinal Obstruction: A blockage in the intestine can cause severe abdominal pain, vomiting, and constipation. It requires urgent medical attention. + Pancreatitis: Inflammation of the pancreas can cause severe abdominal pain, nausea, vomiting, and can be life-threatening if not promptly treated.
  • Rare Diagnoses + Porphyria: A group of disorders that can cause abdominal pain, among other symptoms, due to a buildup of natural chemicals that produce porphyrin in the body. + Lead Poisoning: Can cause abdominal pain, constipation, and other systemic symptoms. + Abdominal Migraine: A condition that causes recurrent episodes of severe abdominal pain, often accompanied by other migraine symptoms like headache and nausea. + Intussusception: A condition where a part of the intestine slides into an adjacent part, causing bowel obstruction and severe abdominal pain. It's more common in children but can occur in adults.

Each of these diagnoses has distinct characteristics and risk factors, and a thorough medical history, physical examination, and sometimes diagnostic tests are necessary to determine the underlying cause of abdominal pain.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.