From the Guidelines
Bupropion is commonly associated with side effects such as dry mouth and insomnia, which are dose-related and typically do not lead to drug discontinuation. The most common adverse effects that lead to drug discontinuation are tremor, rash, headache, and urticaria, with dropout rates ranging from 7% to 12% in clinical trials 1. When used for depression and smoking cessation, bupropion has been linked to a small increased risk of seizures, particularly in individuals with a history of seizures or structural brain lesions 1. Some key points to consider when taking bupropion include:
- Dry mouth and insomnia are common side effects, but often diminish over time as the body adjusts to the medication
- Headache, rash, and urticaria are also possible side effects, and may lead to drug discontinuation in some cases
- Seizures are a rare but serious side effect, occurring in about 1 in 1000 patients, especially those with a history of seizures or brain lesions 1
- Taking the medication earlier in the day and staying well-hydrated may help minimize sleep disturbances and dry mouth, respectively. It's essential to discuss any concerns or side effects with a healthcare provider, especially if severe side effects occur, such as seizures, allergic reactions, or significant mood changes, including increased suicidal thoughts.
From the FDA Drug Label
The most common side effects of bupropion hydrochloride extended-release tablets (XL) include: • trouble sleeping • feeling anxious • stuffy nose • nausea • dry mouth • constipation • dizziness • joint aches
The most common side effects of bupropion (Wellbutrin) are:
- Trouble sleeping
- Feeling anxious
- Stuffy nose
- Nausea
- Dry mouth
- Constipation
- Dizziness
- Joint aches 2
From the Research
Common Side Effects of Bupropion
The most common side effects of bupropion include:
- Insomnia 3, 4, 5, 6
- Dry mouth 3, 4, 5, 7, 6
- Headache 3, 4, 6
- Nausea 3, 4, 5, 6
- Anxiety 3
- Dizziness 4, 6
- Constipation 6
- Tremor 6
- Agitation 6
- Vomiting 6
- Migraines 6
Serious Side Effects
More serious side effects of bupropion include:
Management of Side Effects
Side effects can often be managed by reducing the dose of bupropion 3 or by gradual titration to the maximum dose 6.