Can creatine supplementation cause pancreatitis?

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Last updated: March 9, 2025 • View editorial policy

From the Research

There is no established evidence that creatine causes pancreatitis, and it is generally considered safe when used at recommended doses. The provided evidence does not support a link between creatine supplementation and pancreatitis. Pancreatitis is typically caused by gallstones, alcohol consumption, certain medications, high triglyceride levels, or other medical conditions 1, 2, 3, 4, 5. While some users report mild side effects like stomach discomfort, bloating, or nausea, there are no well-documented cases linking creatine supplementation directly to pancreatitis. If you're experiencing symptoms of pancreatitis (severe abdominal pain, nausea, vomiting) while taking creatine, you should stop the supplement immediately and seek medical attention. These symptoms are likely unrelated to creatine use, but a healthcare provider can properly diagnose the cause. As with any supplement, it's advisable to consult with a healthcare provider before starting creatine, especially if you have existing health conditions or take other medications. Key points to consider:

  • Pancreatitis is a serious condition that requires medical attention
  • Creatine is a widely used dietary supplement that helps increase muscle strength and performance during high-intensity exercise
  • There are no well-documented cases linking creatine supplementation directly to pancreatitis
  • If symptoms of pancreatitis occur, stop the supplement and seek medical attention
  • Consult with a healthcare provider before starting creatine, especially if you have existing health conditions or take other medications. The most recent and highest quality study 3 does not mention creatine as a cause of pancreatitis, further supporting the conclusion that creatine is not a known cause of pancreatitis.

References

Research

Nutrition therapy in acute and chronic pancreatitis.

Medicine and pharmacy reports, 2021

Research

Nutrition therapy in critically ill patients with severe acute pancreatitis.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2024

Research

Severe acute pancreatitis: nutritional management in the ICU.

Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2004

Research

Nutrition support in acute pancreatitis.

JOP : Journal of the pancreas, 2008

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.