How can you diagnose a peroneal nerve injury?

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Last updated: August 20, 2025View editorial policy

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Diagnosis of Peroneal Nerve Injury

The most effective diagnostic approach for peroneal nerve injury includes clinical examination for foot drop, sensory deficits in the lateral leg and dorsum of foot, and confirmatory electrodiagnostic studies. 1

Clinical Examination

Motor Assessment

  • Test for weakness in:
    • Ankle dorsiflexion (tibialis anterior)
    • Foot eversion (peroneus longus and brevis)
    • Toe extension (extensor digitorum longus and extensor hallucis longus)
  • Grade muscle strength on a scale of 0-5:
    • 0: No contraction
    • 1: Visible contraction without movement
    • 2: Movement with gravity eliminated
    • 3: Movement against gravity
    • 4: Movement against resistance
    • 5: Normal strength

Sensory Assessment

  • Check for sensory deficits in:
    • Lateral aspect of the leg
    • Dorsum of the foot
    • First web space (deep peroneal nerve)
  • Assess for:
    • Numbness
    • Paresthesia
    • Dysesthesia

Special Tests

  • Tinel's sign: Percussion over the fibular head or along the nerve course eliciting tingling or electric sensations
  • Assess for foot drop during gait
  • Look for compensatory steppage gait (high stepping to clear the foot)

Advanced Diagnostic Testing

Electrodiagnostic Studies

  • Nerve conduction studies (NCS) and electromyography (EMG) are essential for:
    • Confirming diagnosis
    • Determining severity (partial vs. complete)
    • Localizing the site of injury
    • Establishing prognosis 1, 2

Imaging

  • MRI of the knee/leg:

    • Highly sensitive for identifying nerve compression at the fibular head
    • Can detect associated soft tissue injuries, masses, or anatomical variants 1, 3
    • Particularly useful in traumatic cases or when associated with multiligament knee injuries 4
  • Ultrasound:

    • Allows dynamic assessment of the nerve
    • Can guide interventional procedures
    • Useful for detecting nerve subluxation or dislocation 1

Common Mechanisms of Injury to Check For

  • Direct trauma to fibular head
  • Knee dislocation (95.3% associated with ACL tears) 4
  • Prolonged external compression (e.g., improper positioning during surgery) 5, 1
  • Stretch injuries from leg positioning (especially lithotomy position) 1
  • Habitual leg crossing
  • Tight casts or braces

Differential Diagnosis

  • L5 radiculopathy
  • Sciatic neuropathy
  • Lumbosacral plexopathy
  • Motor neuron disease
  • Anterior compartment syndrome

Pitfalls to Avoid

  • Failing to assess for associated vascular injuries, especially with knee dislocations 1
  • Overlooking partial nerve injuries that may have better recovery potential 6
  • Delaying diagnosis beyond 3-4 months, which can reduce surgical success rates 7
  • Not considering nerve compression at multiple sites (double crush syndrome)
  • Neglecting to protect the common peroneal nerve during surgical procedures, particularly when patients are in lithotomy position 1, 5

Early and accurate diagnosis is crucial as timely intervention significantly improves outcomes. Patients with partial nerve injuries have much better recovery potential (83% regain antigravity ankle dorsiflexion) compared to complete injuries (38%) 6.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Guideline

Peroneal Nerve Lesion Treatment Guidelines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Is peroneal nerve injury associated with worse function after knee dislocation?

Clinical orthopaedics and related research, 2014

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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