Differential Diagnosis for Eyelid Lesion with Cold Symptoms

• Single most likely diagnosis
  • Blepharitis: This condition is characterized by inflammation of the eyelids, often associated with redness, swelling, and itching. It can be exacerbated by cold symptoms and is a common condition that matches the patient's presentation.
• Other Likely diagnoses
  • Hordeolum (Stye): A localized infection or inflammation of the eyelid margin, which can cause a pimple-like lesion, redness, swelling, and itching. It's a common condition that can occur in the context of cold symptoms.
  • Allergic Conjunctivitis: This condition can cause itching, redness, and swelling of the eyelids, often in response to allergens that may also trigger cold-like symptoms.
  • Eczema (Atopic Dermatitis): A chronic skin condition that can cause itching, redness, and swelling, including on the eyelids. It may flare up during cold weather or with cold symptoms.
• Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
  • Orbital Cellulitis: A serious infection of the tissues surrounding the eye, which can cause redness, swelling, and pain. Although less likely, it's a critical diagnosis to consider due to its potential for serious complications, including vision loss.
  • Herpes Zoster (Shingles): Reactivation of the varicella-zoster virus can cause a painful rash, which if it involves the eye (herpes zoster ophthalmicus), can lead to serious complications. Early recognition and treatment are crucial.
• Rare diagnoses
  • Sarcoidosis: A systemic disease that can cause granulomatous inflammation in various parts of the body, including the eyes. It might present with eyelid swelling and skin lesions, among other symptoms.
  • Angioedema: A condition characterized by rapid swelling of the dermis, subcutaneous tissue, mucosa, and submucosal tissues. It can cause significant swelling of the eyelids and is considered a medical emergency if it involves the airway.