From the Research
Bupropion (Wellbutrin) typically takes 4-8 weeks to reach its full effectiveness for ADHD symptoms, though some patients may notice initial improvements within 1-2 weeks. The medication is usually started at a lower dose, such as 150 mg once daily, and may be increased to 300 mg daily (often split into two doses) after several days if tolerated well. Unlike stimulant medications that work immediately, Wellbutrin works gradually by increasing levels of dopamine and norepinephrine in the brain, neurotransmitters involved in attention and focus. While not FDA-approved specifically for ADHD, it's prescribed off-label, particularly for patients who cannot tolerate stimulants or have co-occurring depression.
Key Points to Consider
- Bupropion has been shown to be effective in reducing ADHD symptoms in adults, with a significant difference in symptom severity compared to placebo 1.
- The medication is generally well-tolerated, with a similar proportion of participants withdrawing due to adverse effects compared to placebo 1.
- Individual response to bupropion may vary, and some patients may require a full 2-3 months to determine if the medication is providing adequate symptom relief.
- Bupropion may be a useful alternative for patients who cannot tolerate stimulants or have co-occurring depression, as it has been shown to be effective in improving ADHD symptoms in these populations 2, 3.
Important Considerations for Clinical Practice
- Patients should maintain consistent daily dosing and avoid abrupt discontinuation to minimize the risk of side effects.
- Healthcare providers should closely monitor patients for effectiveness and side effects during the initial adjustment period.
- Bupropion may be used off-label for ADHD, and healthcare providers should carefully weigh the potential benefits and risks of treatment in individual patients.