Cushing's Triad is Present in Transtentorial (Uncal) Herniation
Cushing's triad (hypertension, bradycardia, and irregular respiration) is characteristic of transtentorial herniation, specifically uncal herniation, where increased intracranial pressure causes compression of the brainstem.
Pathophysiology of Transtentorial Herniation
Transtentorial herniation occurs when brain tissue is displaced through the tentorial notch due to increased intracranial pressure. This can happen in two main forms:
Uncal (lateral) herniation:
- The uncus of the temporal lobe is pushed medially and downward through the tentorial notch
- Compresses the midbrain and oculomotor nerve (CN III)
- Leads to Cushing's triad as a response to brainstem compression
Central (downward) herniation:
- Downward displacement of the diencephalon and midbrain through the tentorial notch
- Often occurs with diffuse cerebral edema or large supratentorial masses
Clinical Manifestations of Transtentorial Herniation
Cushing's Triad
- Hypertension: Systolic blood pressure increases as a compensatory mechanism to maintain cerebral perfusion
- Bradycardia: Parasympathetic response to increased intracranial pressure
- Irregular respiration: Due to compression of respiratory centers in the brainstem
Other Clinical Signs
- Pupillary dilation (initially unilateral) due to CN III compression
- Decreased level of consciousness
- Hemiparesis (often contralateral)
- Decerebrate or decorticate posturing
- Cheyne-Stokes respiration or other abnormal breathing patterns
Differential Diagnosis
It's important to distinguish transtentorial herniation from other types of brain herniation:
- Subfalcine herniation: Cingulate gyrus herniates under the falx cerebri
- Tonsillar herniation: Cerebellar tonsils herniate through the foramen magnum
- Upward transtentorial herniation: Cerebellar tissue herniates upward through the tentorial notch
- Transcalvarial herniation: Brain tissue herniates through a skull defect
Management Considerations
The presence of Cushing's triad indicates a neurosurgical emergency requiring immediate intervention to reduce intracranial pressure:
Immediate measures:
- Elevate head of bed to 30 degrees
- Hyperventilation (temporarily)
- Mannitol or hypertonic saline administration
- Neurosurgical consultation
Definitive treatment:
- Surgical decompression
- Evacuation of mass lesion if present
- Management of underlying cause (tumor, hemorrhage, etc.)
Common Pitfalls
- Cushing's triad may not be present in all cases of transtentorial herniation
- Bradycardia may be a late finding; tachycardia can occur in early stages
- Misinterpreting Cushing's triad as indicating cardiac or respiratory pathology rather than increased intracranial pressure
- Delaying neurosurgical intervention while pursuing other diagnostic studies
Early recognition of Cushing's triad and prompt intervention are critical for preventing irreversible brain damage and death in patients with transtentorial herniation.