From the Research
Effect of Clopidogrel on Prothrombin Time
- The effect of clopidogrel on prothrombin time is not consistently reported across studies 1, 2, 3, 4, 5.
- A study on healthy male subjects found that co-administration of clopidogrel and rivaroxaban had no significant effect on prothrombin time compared to rivaroxaban alone 1.
- Another study on cats with asymptomatic hypertrophic cardiomyopathy found that clopidogrel therapy did not significantly affect prothrombin time 2.
- A study on patients undergoing coronary artery stenting found that clopidogrel produced a prolongation in the time to platelet-fibrin clot formation, but this was measured using thrombelastography and not directly related to prothrombin time 3.
- A study on patients with nonvalvular atrial fibrillation found that aspirin plus clopidogrel did not significantly affect coagulation parameters, including prothrombin fragment 1 + 2 4.
- A study on patients with peripheral arterial disease found that clopidogrel alone or in combination with other antiplatelet agents decreased circulating tissue factor procoagulant activity, but did not report a direct effect on prothrombin time 5.