How to reconstitute ceftriaxone 1g vial?

Reconstitution of Ceftriaxone 1g Vial

To reconstitute a ceftriaxone 1g vial, add 9.6 mL of appropriate diluent for intravenous administration or 3.6 mL for intramuscular administration. 1

Intravenous Administration

Materials Needed:

• Ceftriaxone 1g powder vial
• Appropriate diluent (sterile water for injection, 0.9% sodium chloride, or 5% dextrose)
• 10 mL syringe
• Needle
• IV administration set (if giving as infusion)

Reconstitution Steps:

1. Add 9.6 mL of diluent to the 1g vial 1
2. Shake well until completely dissolved
3. The resulting concentration will be approximately 100 mg/mL
4. Administer by IV infusion over 30 minutes 1

Storage After Reconstitution:

• Room temperature (25°C): Stable for 2 days
• Refrigerated (4°C): Stable for 10 days 1

Intramuscular Administration

Materials Needed:

• Ceftriaxone 1g powder vial
• Appropriate diluent (sterile water for injection, 0.9% sodium chloride, or 5% dextrose)
• 5 mL syringe
• Needle for reconstitution
• Needle for injection

Reconstitution Steps:

1. For standard 250 mg/mL concentration: Add 3.6 mL of diluent to the 1g vial
2. For higher 350 mg/mL concentration: Add 2.1 mL of diluent to the 1g vial 1
3. Shake well until completely dissolved
4. Withdraw entire contents into syringe
5. Inject deep into a large muscle (e.g., gluteal muscle)

Storage After Reconstitution:

• Room temperature (25°C): Stable for 24 hours
• Refrigerated (4°C): Stable for 3 days 1

Important Considerations

Compatibility:

• Do NOT use diluents containing calcium, such as Ringer's solution or Hartmann's solution, as particulate formation can result 1
• Incompatible with vancomycin, amsacrine, aminoglycosides, and fluconazole in admixtures 1

Administration Warnings:

• For IM administration, inject well within the body of a relatively large muscle
• Aspirate before injection to avoid inadvertent intravascular administration 1
• For IV administration, never administer as a bolus; always infuse over 30 minutes 1

Stability:

• The color of reconstituted solution ranges from light yellow to amber depending on storage time, concentration, and diluent used 1
• Color change within this range does not indicate loss of potency 1

Following these guidelines ensures proper reconstitution and administration of ceftriaxone 1g, maximizing its effectiveness while minimizing potential complications.