Essential Blepharospasm: This is a condition characterized by involuntary spasms or twitching of the eyelid muscles. It is often benign and can be related to fatigue, stress, or eye strain, making it a common and likely diagnosis for eye lip spasm/twitch.

Hemifacial Spasm: A condition that causes involuntary twitching of the muscles on one side of the face, including the eyelids and lips. It can be caused by a variety of factors, including nerve compression.
Tardive Dyskinesia: A side effect of long-term use of neuroleptic drugs, characterized by repetitive, involuntary, purposeless movements such as facial twitching.
Dystonia: A disorder characterized by involuntary muscle contractions, which can cause repetitive movements or abnormal postures, including eye and lip spasms.

Multiple Sclerosis: Although less common, multiple sclerosis (MS) can cause a wide range of neurological symptoms, including vision problems and facial spasms. MS is a condition that affects the central nervous system and can have severe consequences if not diagnosed and treated properly.
Stroke or Transient Ischemic Attack (TIA): Facial weakness or spasms can be a symptom of a stroke or TIA. These are medical emergencies that require immediate attention to prevent serious brain damage or death.
Brain Tumors: Tumors in the brain can cause a variety of neurological symptoms depending on their location, including facial spasms or twitching.

Botulism: A rare but serious illness caused by a toxin that can lead to muscle weakness, including facial muscles, resulting in spasms or twitching.
Myasthenia Gravis: An autoimmune disorder that can cause muscle weakness, including the muscles around the eyes, leading to drooping eyelids or spasms.
Wilson's Disease: A genetic disorder that leads to copper accumulation in the body, causing neurological symptoms, including tremors and involuntary movements, which can include facial spasms.